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The Science Behind Every Product
Every ingredient has earned its place
FOCUS COMPLEX
Formulated for the brain fog, low mood, and mental fatigue that accompany oestrogen fluctuation. Eight clinically-selected actives targeting cognition, cellular energy, and neurological resilience.
Mental Clarity · Memory Mood· Cognitive Energy· Neurological Resilience
Inside the Formula
Crocus sativus — 2% safranal
Dose: 30 mg
Rationale: Evidence-backed mood and cognitive support; clinically shown to reduce anxiety and brain-fog-related low mood during hormonal transition at this dose.
Pharmaceutical grade
Dose: 175 mg
Rationale: Raises brain phosphatidylcholine levels supporting neuronal membrane integrity, working memory, and acetylcholine synthesis — the neurotransmitter most affected by oestrogen decline.
Coenzyme Q10 — mitochondrial energy co-factor
Dose: 150 mg
Rationale: Powers mitochondrial ATP production in brain cells; levels decline significantly with age and hormonal change, making targeted support clinically meaningful.
Pyridoxine HCl
Dose: 5 mg
Rationale: Co-factor for serotonin and dopamine synthesis; supports cognitive function and mood regulation at every stage of hormonal transition.
Bisglycinate — highest bioavailability chelate
Dose: 10 mg
Rationale: Co-factor for over 300 enzymes including those governing memory formation and neuroplasticity; deficiency is associated with cognitive decline in perimenopausal women.
MK-7, natto-derived
Dose: 100 µg
Rationale: Activates Matrix Gla Protein to protect cerebrovascular tissue and direct calcium away from artery walls; synergistic with D3 for vascular-driven brain health.
L-Selenomethionine — organic, superior absorption
Dose: 55 µg
Rationale: Antioxidant protecting neuronal tissue from oxidative stress; supports thyroid hormone conversion (T4→T3) whose decline directly impairs cognitive clarity.
Cholecalciferol — vegetarian source (1,000 IU)
Dose: 55 µg
Rationale: Neurosteroid precursor; deficiency is independently associated with cognitive decline and low mood, particularly prevalent in women with limited sun exposure.
On Citicoline: Unlike standard choline sources, CDP-Choline crosses the blood-brain barrier efficiently and is the only choline precursor with direct clinical evidence for improved memory and attention. The saffron extract in this formula is standardised to 2% safranal — the active constituent with the strongest evidence base for mood and cognition during hormonal transition.
MAGNESIUM BISGLYCINATE
Over 70% of perimenopausal women are magnesium-deficient — affecting sleep quality, muscle tension, anxiety, and bone density simultaneously. Bisglycinate delivers the highest bioavailability of any magnesium form with zero digestive side effects.
Deep Sleep· Muscle Relaxation· Reduced Anxiety· Bone density· Mood stability
Inside the Formula
Bisglycinate — amino acid chelate
Dose: 100 mg elemental (833 mg compound weight)
Rationale: Chelated to glycine for approximately 80% bioavailability versus 4% for magnesium oxide; glycine itself is independently calming and promotes restorative sleep onset via GABA modulation.
Why bisglycinate? Magnesium oxide — the form in most supplement aisle products — has a bioavailability of only 4% and commonly causes digestive discomfort. Bisglycinate delivers up to 80% absorption per dose, with zero GI side effects. The clinical difference is significant and is the reason this form costs more to produce.
VITALITY COMPLEX
Perimenopausal fatigue is biochemical, not motivational. Declining oestrogen impairs mitochondrial efficiency, iron metabolism, and methylation simultaneously. Nine targeted actives address all three pathways at once.
Sustained energy · Reduced fatigue · Iron support · Cellular metabolism · Cardiovascular health
Inside the Formula
Rhodiola rosea
Dose: 150 mg
Rationale: Adaptogenic herb with robust clinical evidence for reducing mental and physical fatigue; particularly effective for the burnout-pattern tiredness characteristic of perimenopausal stress.
Punica granatum — 40% ellagic acid
Dose: 125 mg
Rationale: Rich in ellagitannins that support mitochondrial renewal (mitophagy) and cardiovascular health; also supports oestrogen metabolism during hormonal transition.
Coenzyme Q10 — mitochondrial energy co-factor
Dose: 100 mg
Rationale: Essential electron carrier in the mitochondrial respiratory chain; supports cellular ATP production, with levels declining significantly post-40.
L-Ascorbic Acid
Dose: 40 mg
Rationale: Enhances non-haem iron absorption; supports adrenal function for cortisol regulation and acts as antioxidant protection for mitochondria.
Bisglycinate — non-constipating chelated form
Dose: 7 mg
Rationale: Superior absorption with zero gastrointestinal side effects; essential for haemoglobin synthesis and oxygen transport in women experiencing perimenopausal heavy bleeding.
Pyridoxal-5-Phosphate (P5P) — active metabolic form
Dose: 2.5 mg
Rationale: P5P requires no liver conversion; supports haemoglobin synthesis, serotonin production, and energy metabolism as an active co-factor in over 100 enzymatic reactions.
BioPerine® — 95% piperine, Piper nigrum
Dose: 2.5 mg
Rationale: Patented extract clinically proven to enhance bioavailability of co-delivered nutrients by up to 20-fold — ensuring full therapeutic benefit from every ingredient.
5-MTHF Calcium — methylated, bioavailable form
Dose: 200 µg
Rationale: Methylated folate bypasses the MTHFR gene variant affecting up to 40% of women; supports the methylation cycle central to energy production and cardiovascular health.
Methylcobalamin — neurologically active form
Dose: 25 µg
Rationale: Directly usable without liver conversion; supports myelin sheath integrity, cellular energy, and prevents the fatigue associated with B12 insufficiency.
On BioPerine®: Without a bioavailability enhancer, many nutrients pass through the digestive tract without full absorption. Sabinsa’s patented BioPerine® is the standard used in clinical trials and is supported by over 20 human studies confirming its absorption-enhancing effect on co-delivered compounds.
HARMONY COMPLEX
Designed for the emotional and hormonal turbulence of perimenopause — the hot flushes, the irritability, the anxiety, the sense of losing yourself. Seven evidence-based actives to restore equilibrium and reduce vasomotor symptoms.
Hormonal balance · Hot flush reduction · Mood uplift · Stress resilience · Bone & vascular health
Inside the Formula
Trifolium pratense — 8% isoflavones
Dose: 250 mg
Rationale: Phytoestrogenic isoflavones that bind weakly to oestrogen receptors, buffering oestrogen decline responsible for hot flushes; clinical meta-analyses confirm meaningful reduction in flush frequency.
KSM-66® — Withania somnifera, 5% withanolides
Dose: 150 mg
Rationale:Regulates the HPA axis and lowers cortisol, directly counteracting the stress amplification that worsens every hormonal symptom during perimenopause.
Salvia officinalis — 20:1 concentration
Dose: 150 mg
Rationale: Clinical evidence for significant reduction in hot flush frequency and severity in women aged 40–65; also supports memory via acetylcholinesterase inhibition.
Crocus sativus — 2% safranal
Dose: 15 mg
Rationale: Supports mood, reduces anxiety, and improves sleep quality during hormonal transition; evidence-based botanical for perimenopausal emotional wellbeing.
MK-7, natto-derived
Dose: 50 µg
Rationale: Activates osteocalcin for bone mineralisation and Matrix Gla Protein for arterial protection; paired with D3 to ensure calcium is directed into bone rather than soft tissue.
Cholecalciferol — vegetarian source (500 IU)
Dose: 12.5 µg
Rationale: Supports hormone synthesis, immune regulation, and mood; co-dosed with K2 for calcium metabolism and bone health during perimenopause.
Pyridoxine HCl
Dose: 2.5 mg
Rationale: Supports progesterone receptor function and serotonin synthesis, addressing the mood dysregulation of luteal phase changes in perimenopause.
On sage and saffron: Sage Leaf Extract at 20:1 concentration delivers the equivalent of 3,000 mg of fresh leaf per dose. The saffron extract in Harmony Complex is standardised to 2% safranal and is included at 15 mg — a dose supported by clinical evidence for mood and emotional wellbeing during perimenopause.
DESIRE BLEND
Low libido in perimenopause is hormonal, neurological, and vascular — not psychological. Six actives target testosterone-pathway balance, pelvic circulation, phytoestrogenic support, and the neurotransmitter drive that oestrogen normally protects.
Restored desire · Hormonal drive · Vaginal health · Pelvic circulation · Confidence & energy
Inside the Formula
Trifolium pratense — 8% isoflavones
Dose: 250 mg
Rationale: Phytoestrogenic support for oestrogen receptor-mediated vaginal tissue health; reduces dryness and discomfort that directly impair sexual comfort and desire.
Asparagus racemosus root
Dose: 200 mg
Rationale: Phytoestrogenic Ayurvedic adaptogen with clinical evidence for improving vaginal lubrication, sexual frequency, and overall sexual function scores in perimenopausal women.
Lepidium meyenii — 10:1 concentration
Dose: 100 mg
Rationale: Improves sexual desire and satisfaction through glucosinolate pathways that operate independently of oestrogen; RCT evidence in postmenopausal women confirms efficacy.
KSM-66® — Withania somnifera, 5% withanolides
Dose: 100 mg
Rationale: Reduces cortisol-mediated suppression of sexual desire; supports DHEA and testosterone precursor pathways, the primary hormonal drivers of libido.
Ginkgo biloba — 20:1 concentration
Dose: 60 mg
Rationale: Vasodilatory action increases microcirculation in pelvic tissue, directly addressing reduced genital blood flow that impairs arousal and sensation..
Bisglycinate — highest bioavailability chelate
Dose: 2.5 mg
Rationale: Essential co-factor for testosterone biosynthesis and ovarian steroidogenesis; deficiency is significantly associated with reduced sexual desire.
Pyridoxine HCl
Dose: 2.5 mg
Rationale: Supports dopamine synthesis — the primary neurotransmitter of desire — and progesterone metabolism, both directly implicated in perimenopausal libido decline.
Trifolium pratense — 8% isoflavones
Dose: 250 mg
Rationale: Phytoestrogenic support for oestrogen receptor-mediated vaginal tissue health; reduces dryness and discomfort that directly impair sexual comfort and desire.
Formulation Principle: Every ingredient in Desire Blend has peer-reviewed evidence specifically in women’s sexual health. This is not male performance research applied to women — it is a formula built on clinical data relevant to the hormonal and physiological reality of perimenopause.
COLLAGEN POWDER
Women lose up to 30% of dermal collagen in the first five years after menopause. Our bovine collagen powder combines Type 1 peptides with every co-factor required for the body to synthesise new collagen — not just consume it.
Skin elasticity · Joint comfort · Hair thickness · Nail strength · Gut integrity
Inside the Formula
Hydrolysed collagen peptides — low molecular weight
Dose: 984 mg
Rationale: Type 1 bovine collagen peptides targeting skin elasticity, joint comfort, hair strength, and nail integrity; hydrolysed for complete intestinal absorption and confirmed dermal delivery.
Fermentation-derived, low molecular weight
Dose: 9.84 mg
Rationale: Fills the extracellular matrix alongside collagen; low molecular weight HA is orally bioavailable and clinically shown to improve skin hydration and reduce wrinkle depth.
L-Ascorbic Acid
Dose: 5.91 mg
Rationale: Indispensable co-factor for prolyl hydroxylase — the enzyme that cross-links collagen chains into stable triple-helix structures; without it, consumed collagen cannot be properly incorporated into tissue.
On co-factors: The majority of collagen supplements contain only the peptides. Without Vitamin C, the proline residues in collagen chains cannot be hydroxylated — a step that is chemically non-negotiable for stable collagen formation. Zourra includes Vitamin C in every dose to ensure the collagen you take can actually be used by your body.
Science-backed, evidence-led supplements made for women over 40.
Science-backed, evidence-led supplements made for women over 40.